Magnesium carbonate is an important multifunctional excipient in oral oxytetracycline preparations. It not only improves the manufacturing process (as a flow aid, for shaping/compression, and filling) but also provides a certain antacid buffering effect during administration, protecting the stability of the active ingredient. By rationally designing the dosage and particle size distribution, it can enhance the quality, stability, and patient experience of the preparation. It is a practical means to improve the standard of oxytetracycline preparations.
1. Improves Powder Flowability
Magnesium carbonate possesses good flowability and anti-caking properties.
As a flow aid, it helps oxytetracycline powder pass smoothly through pharmaceutical processing equipment, improving the efficiency and consistency of automated tablet pressing or capsule filling.
2. Acts as a Filler and Diluent
Increases the volume of tablets or capsules, facilitating shaping/compression and accurate dosing.
Ensures uniform distribution in low-dose oxytetracycline preparations, improving dose accuracy.
3. Buffers Gastric Acid and Protects the Active Ingredient
Magnesium carbonate is a weakly alkaline substance and can neutralize some gastric acid.
This reduces the hydrolysis and degradation of oxytetracycline under acidic conditions, improving its bioavailability after oral administration.
4. Enhances Preparation Stability
It possesses slight hygroscopicity and anti-caking ability, inhibiting deliquescence.
This helps reduce the risk of physical deterioration during long-term storage.
5. Good Safety and Cost-Effectiveness
Widely used in pharmaceutical excipients, it is readily available and inexpensive.
It has good compatibility with various excipients, facilitating large-scale pharmaceutical production.