Hebei Messi Biology Co., Ltd. said that magnesium hydroxide is relatively better for treating hyperacidity. Magnesium hydroxide and aluminum hydroxide will generate magnesium chloride and aluminum chloride after neutralization with gastric acid. Aluminum ions are toxic to the human body and are not recommended for large amounts. Patients with excessive gastric acid (the main component is dilute hydrochloric acid) often take medicines containing magnesium hydroxide to relieve pain. The chemical equation of the reaction is Mg(OH)2+2HClMgCl2+2H2O
The medical and food grade magnesium hydroxide independently developed and produced by Hebei Meixi Biological Co., Ltd. is chemically synthesized magnesium hydroxide obtained by removing heavy metals and other impurities through a special process. It has the characteristics of low heavy metal content and low trace element content. The product complies with European and American Pharmacopoeia standards.
Medical and food grade magnesium hydroxide is a salt laxative with antacid effect. Its preparations are mainly used for gastric/duodenal ulcers, gastritis, and upper gastrointestinal dysfunction. It is widely used in medicine to make antacids and laxatives. It can neutralize gastric acid and has a fast, strong and long-lasting effect. It does not produce carbon dioxide and protects ulcer surfaces. Used in the field of biopharmaceuticals as neutralizer, heavy metal adsorbent, anti-caking agent, filter aid, desulfurizer, lead removal, mercury removal, heavy metal removal and decolorizing agent. It can also be used in health care products and food as anti-caking agent. Agents, antacids, filter aids, antibacterial colorants, etc.
Hebei Messi Biology Co., Ltd. said that it used nano-magnesium hydroxide as a carrier to study the loading of norfloxacin drug and the impact of the nano-magnesium hydroxide carrier on the antibacterial effect of Escherichia coli. Research shows that the nanoparticles synthesized by co-precipitation method have a more regular sheet structure, good dispersion, and the size of the nanoparticles on the 101 plane is about 14.0nm. Through Fourier transform infrared spectroscopy analysis, it was found that no new characteristic peaks appeared after magnesium hydroxide and norfloxacin were loaded, and they were mainly combined by physical entrapment. Nanomagnesium hydroxide carriers with different contents were combined with norfloxacin, and the drug loading capacity and encapsulation efficiency could be calculated based on the amount of norfloxacin in the supernatant.
When the content of magnesium hydroxide increases from 1 mg to 2 mg, the drug loading capacity increases from 40.58% to 59.00%, and the encapsulation rate increases from 81.15% to 88.50%, which shows that the dosage of magnesium hydroxide can affect its effect on norfloxacin. drug loading and encapsulation efficiency. In addition, norfloxacin, nano-magnesium hydroxide carrier and norfloxacin-nano magnesium hydroxide carrier were co-cultured with Escherichia coli, and the OD600 and spread plate experiments were used to detect the lethality of bacteria after 24 hours. Norfloxacin’s effect on Escherichia coli The inhibition rate was only 23%, but the inhibition rate increased to 62% after loading with magnesium hydroxide. This shows that norfloxacin can significantly improve the antibacterial effect of the drug on E. coli under the synergistic effect of magnesium hydroxide.